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Conformational studies of haloperidol

Conformational studies of haloperidol

Authors :
Paul A. Karr
Melvin E. Zandler
Charles E. Keller
W. Robert Carper
Source :
Structural Chemistry. 3:195-201
Publication Year :
1992
Publisher :
Springer Science and Business Media LLC, 1992.

Abstract

The high field1H,19F, and13C NMR spectra of haloperidol (HP) in CDCl3 solution were recorded and analyzed with the aid of both homonuclear (H, H-COSY, H, H-COSYLR) and heteronuclear (H,C-COSY) chemical shift correlation experiments. Through space interactions between (1) the piperidine ring and the chlorinated phenyl ring and (2) the fluorinated phenyl ring and a methylene group were identified using phase sensitive Nuclear Overhauser and Exchange Spectroscopy (NOESY). The NOESY results are consistent with a planar structure rather than a folded version of haloperidol.

Details

ISSN :
15729001 and 10400400
Volume :
3
Database :
OpenAIRE
Journal :
Structural Chemistry
Accession number :
edsair.doi...........3555812df1e57e21912156c41a81e34d
Full Text :
https://doi.org/10.1007/bf00678417