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Conformational studies of haloperidol
Conformational studies of haloperidol
- Source :
- Structural Chemistry. 3:195-201
- Publication Year :
- 1992
- Publisher :
- Springer Science and Business Media LLC, 1992.
-
Abstract
- The high field1H,19F, and13C NMR spectra of haloperidol (HP) in CDCl3 solution were recorded and analyzed with the aid of both homonuclear (H, H-COSY, H, H-COSYLR) and heteronuclear (H,C-COSY) chemical shift correlation experiments. Through space interactions between (1) the piperidine ring and the chlorinated phenyl ring and (2) the fluorinated phenyl ring and a methylene group were identified using phase sensitive Nuclear Overhauser and Exchange Spectroscopy (NOESY). The NOESY results are consistent with a planar structure rather than a folded version of haloperidol.
- Subjects :
- Chemistry
Stereochemistry
Condensed Matter Physics
Ring (chemistry)
Homonuclear molecule
NMR spectra database
chemistry.chemical_compound
Heteronuclear molecule
Haloperidol
medicine
Piperidine
Physical and Theoretical Chemistry
Methylene
Two-dimensional nuclear magnetic resonance spectroscopy
medicine.drug
Subjects
Details
- ISSN :
- 15729001 and 10400400
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Structural Chemistry
- Accession number :
- edsair.doi...........3555812df1e57e21912156c41a81e34d
- Full Text :
- https://doi.org/10.1007/bf00678417