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Low Heart Rates Predict Incident Atrial Fibrillation in Healthy Middle-Aged Men
- Source :
- Circulation: Arrhythmia and Electrophysiology. 6:726-731
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- Background— Low resting heart rate (HR) has been associated with atrial fibrillation (AF) in athletes. We aimed to study whether low HR at rest or during exercise testing was a predictor of AF in initially healthy middle-aged men. Methods and Results— A total of 2014 healthy Norwegian men participated in a prospective cardiovascular survey, including a standardized bicycle exercise test in 1972 to 1975. During ≤35 years of follow-up (53 000 person-years of observation), 270 men developed incident AF, documented by scrutiny of health charts in all Norwegian hospitals. Risk estimation was analyzed with Cox proportional hazard models. Low exercise HR after 6 minutes exercise on the moderate workload of 100 W (HR100W) was a predictor of incident AF. Men with HR100W Conclusions— Our data indicate that low exercise HR on a moderate workload is a long-term predictor of incident AF in healthy middle-aged men. Elevated baseline blood pressure substantially amplifies this risk. The present results suggest a relationship between increased vagal tone, high stroke volumes and incident AF, and particularly so in physically fit men.
- Subjects :
- medicine.medical_specialty
business.industry
Physical fitness
Hazard ratio
Absolute risk reduction
Atrial fibrillation
medicine.disease
Confidence interval
Blood pressure
Physiology (medical)
Internal medicine
Heart rate
medicine
Cardiology
Physical therapy
Cardiology and Cardiovascular Medicine
business
Stroke
Subjects
Details
- ISSN :
- 19413084 and 19413149
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Circulation: Arrhythmia and Electrophysiology
- Accession number :
- edsair.doi...........358217769f04a58b26925643e7e9c1c6