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Absence of TLR4 Asp299Gly and Thr399Ile Polymorphisms in Chinese Han Population With Type 2 Diabetes
- Source :
- Laboratory Medicine. 41:559-562
- Publication Year :
- 2010
- Publisher :
- Oxford University Press (OUP), 2010.
-
Abstract
- Objective: This study was performed to detect the association between the Asp299Gly and Thr399Ile polymorphisms of the TLR4 gene and type 2 diabetes in the Chinese Han population. Methods: The study included 856 unrelated individuals with type 2 diabetes and 672 healthy controls. The polymorphisms of the TLR4 gene were examined through denaturing high-performance liquid chromatography. Results: Neither the Asp299Gly nor the Thr399Ile polymorphism was detected in any of the diabetic and healthy subjects. Conclusions: Our finding indicates the Asp299Gly and Thr399Ile polymorphisms of the TLR4 gene are very rare in the Chinese Han population.
Details
- ISSN :
- 19437730 and 00075027
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Laboratory Medicine
- Accession number :
- edsair.doi...........35b8b6b6a74eb24e8209971e44a4b4aa