ChemInform Abstract: De Novo Synthesis of Phenolic Dihydroxanthene Near-Infrared Emitting Fluorophores

We report a flexible de novo synthesis of phenolic dihydroxanthene fluorophores. The synthesis relies on a one-pot formation of an aldehyde intermediate which can be diversified in 60–70% overall yield, providing an efficient access to this family of near-infrared emitting fluorophores.