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Figure S2 from Loss of TOP3B leads to increased R-loop formation and genome instability
- Publication Year :
- 2019
- Publisher :
- The Royal Society, 2019.
-
Abstract
- Topoisomerase III beta (TOP3B) is one of the least-understood members of the topoisomerase family of proteins and remains enigmatic. Our recent data shed light on the function and relevance of TOP3B to disease. A homozygous deletion for the TOP3B gene was identified in a patient with bilateral renal cancer. Analyses in both patient and modelled human cells show the disruption of TOP3B causes genome instability with a rise in DNA damage and chromosome bridging (mis-segregation). The primary molecular defect underlying this pathology is a significant increase in R-loop formation. Our data show that TOP3B is necessary to prevent the accumulation of excessive R-loops and identify TOP3B as a putative cancer gene and support recent data show that R-loops are involved in cancer aetiology.
- Subjects :
- 3. Good health
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........3695526f91b9b4564d504d6d91e7cfaa
- Full Text :
- https://doi.org/10.6084/m9.figshare.10311125.v1