ChemInform Abstract: Synthesis and Biological Evaluation of 23-Oxa-, 23-Thia-, and 23-Oxa- 24-oxo-1α,25-dihydroxyvitamin D3

Authors :: K Allewaert
P. De Clercq
Roger Bouillon
H. Van Baelen
Xu-yang Zhao
M. Vandewalle
Source :: ChemInform. 25
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: The synthesis includes the side-chain construction starting from the Inhoffen-Lythgoe diol and coupling with the A ring. Both 23-oxa- and 23-thia-analogues showed a decreased cell differentiating effect but even a more decreased calcemic effect compared with 1α,25-(OH) 2 D 3 .

Subjects :: Coupling (electronics)
chemistry.chemical_compound
chemistry
1α 25 dihydroxyvitamin d3
Stereochemistry
Diol
polycyclic compounds
General Medicine
Ring (chemistry)
Biological evaluation

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