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A new bibenzyl and a new methylflavan from the tubers of Bletilla striata
- Source :
- Phytochemistry Letters. 44:149-153
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- A new bibenzyl, (+)-(1S)-4ʹ,5ʺ-dihydroxy-1,3ʹ,5ʹ,3ʺ-tetramethoxybibenzyl (1), and a new methylflavan, (2S)-7,4′-dihydroxy-5-methoxy-8-methylflavan (2), together with 10 known compounds were isolated from the methanolic extract of the tubers of Bletilla striata. Their chemical structures were elucidated based on spectrometric data interpretation, especially 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) data. All isolates (1 - 12) were evaluated for their inhibitory properties on nitric oxide production induced in RAW 264.7 cells, and dihydrophenantrenes 4 and 6 exhibited the best inhibitory effects with IC50 values of 29.5, and 6.5 μM, respectively. Additionally, significant activity possessed phenantrene 5 and methylflavane 2 with IC50 values of 38.9, and 44.9 μM, respectively.
- Subjects :
- Circular dichroism
biology
Data interpretation
Plant Science
biology.organism_classification
Biochemistry
Nitric oxide
chemistry.chemical_compound
chemistry
Bletilla striata
Ic50 values
Bibenzyl
Agronomy and Crop Science
Two-dimensional nuclear magnetic resonance spectroscopy
Biotechnology
Nuclear chemistry
Subjects
Details
- ISSN :
- 18743900
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Phytochemistry Letters
- Accession number :
- edsair.doi...........37b07f104402e64d36abb40bfc8d9778