Synthesis and Crystal Structure of Chalcone Derivatives and Their Effect on α-Glucosidase

Five chalcone derivatives (E)-1-(2-(2-bromoethoxy)phenyl)-3-phenylprop-2-en-1-one(1), (E)-1-(2-(3-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one(2),(E)-1-(2-(4-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one(3),(E)-1-(2-(5-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one(4),(E)-1-(2-(6-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one(5) were synthesized and characterized by 1H NMR, HRMS. The crystalline structures of compounds 4 and 5 were further characterized by X-ray crystal diffraction. Among the five compounds, 1 and 2 showed inhibitory activity on α-glucosidase, but 4 and 5 increased the activity of α-glucosidase. Five chalcone derivatives were synthesized and characterized by 1H MNR and HRMS. The crystalline structures of two compounds were further characterized by X-ray crystal diffraction. Two of the compounds have the ability to inhibit α-glucosidase, and two different compounds have the ability to promote α-glucosidase.