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FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8+ T Cells During Ischemic Stroke
- Source :
- Translational Stroke Research. 11:747-761
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL specific on CD8+ T cells protected against brain damage and neuron loss. Proteomic analysis identified that PDPK1 functioned downstream of FasL signaling and inhibition of PDPK1 effectively reduced cytotoxicity of CD8+ T cells and improved ischemic neurological deficits. Taken together, these results highlight an intrinsic FasL-PDPK1 pathway regulating the cytotoxicity of CD8+ T cells in ischemic stroke.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Neurology
business.industry
General Neuroscience
Brain damage
medicine.disease
Fas ligand
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Cancer research
Medicine
Cytotoxic T cell
Neurology (clinical)
medicine.symptom
Cardiology and Cardiovascular Medicine
Cytotoxicity
business
Stroke
030217 neurology & neurosurgery
CD8
Function (biology)
Subjects
Details
- ISSN :
- 1868601X and 18684483
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Translational Stroke Research
- Accession number :
- edsair.doi...........382e4687d3639bfc92bef67119579c06