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Effects of Pulsatile Reperfusion on Globally Ischemic Myocardium
- Source :
- ASAIO Journal. 39:M438-M443
- Publication Year :
- 1993
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1993.
-
Abstract
- To evaluate the effects of pulsatile reperfusion on the post ischemic myocardium, two categories of sheep were put on cardiopulmonary bypass (CPB). In Category I, the hearts of 23 sheep were arrested by global ischemia for 30 min, reperfused with pulsatile flow in 10 animals (P group), and non pulsatile flow in 13 animals (NP group), and then defibrillated. The incidence of ventricular fibrillation was much higher in the NP group than the P group, 77% versus 40% (p < 0.05). The lipoperoxide products and creatinine kinase from coronary sinus blood were elevated, but there were no significant differences between the two groups during 2 hour reperfusion. In the P group, less ultrastructural damage was observed, and Na+ and H2O accumulations in the subendomyocardium were significantly less than in the NP group, at 7.11 +/- 0.60 versus 9.98 +/- 1.10 mg/g dry weight (p < 0.05) and 82.58 +/- 0.47% versus 84.3 +/- 0.38% (p < 0.05), respectively. In Category II, the ischemic time of 17 sheep (eight in the P group, nine in the NP group) was prolonged to 45 min, and animals were supported by CPB after defibrillation. Myocardial energy phosphates were measured with high-performance liquid chromatography, and triphenyltetrazolium chloride was used to delineate the infarct size. After 2 hour of reperfusion, there were no significant differences in myocardial AMP and ADP between the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- medicine.medical_specialty
Defibrillation
medicine.medical_treatment
Biomedical Engineering
Biophysics
Pulsatile flow
Ischemia
Bioengineering
law.invention
Biomaterials
law
Internal medicine
Cardiopulmonary bypass
Medicine
Coronary sinus
biology
business.industry
Vascular disease
General Medicine
medicine.disease
Anesthesia
Ventricular fibrillation
biology.protein
Cardiology
Creatine kinase
business
Subjects
Details
- ISSN :
- 10582916
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- ASAIO Journal
- Accession number :
- edsair.doi...........38f7883e881e598b0df4135e9280fafa
- Full Text :
- https://doi.org/10.1097/00002480-199307000-00057