ChemInform Abstract: Total Synthesis of (-)-Nupharamine and (+)-3-Epinupharamine via Asymmetric Nitroso Diels-Alder Reaction

Chiral synthesis of (−)-nupharamine and (+)-3-epinupharamine, based on elaboration of the intramolecular asymmetric Diels-Alder reaction of N-acylnitroso compounds and the introduction of the furyl group in a fully stereocontrolled manner, is described.