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National clinical recommendations for the diagnosis and treatment of mastocytosis
- Source :
- Russian journal of hematology and transfusiology. 66:280-311
- Publication Year :
- 2021
- Publisher :
- National Medical Research Center of Hematology of the Ministry of Health of the Russian Federation, 2021.
-
Abstract
- Introduction. Recommendations cover the current state of diagnosis and treatment of mastocytosis.Aim — а consolidation of the Russian experts’ opinion on treatment for adult mastocytosis.Main findings. The recommendations have been developed taking into account foreign literature, national experience and world clinical evidence on therapy for systemic and cutaneous mastocytoses, mast cell leukaemia and other mastocytosis forms. The significance of bone marrow and peripheral blood molecular genetic testing for the presence of KITD816V gene variants is demonstrated. The treatment regimens described are based on midostaurin, imatinib, cladribine, hydroxycarbamide, interferon alfa and haematopoietic stem cell transplantation. Prognosis in different forms of mastocytosis is provided.
- Subjects :
- Oncology
medicine.medical_specialty
Cutaneous Mastocytosis
business.industry
Alpha interferon
Imatinib
Hematology
medicine.disease
Hydroxycarbamide
Transplantation
chemistry.chemical_compound
chemistry
Internal medicine
medicine
Midostaurin
Systemic mastocytosis
business
Interferon alfa
medicine.drug
Subjects
Details
- ISSN :
- 24113042 and 02345730
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Russian journal of hematology and transfusiology
- Accession number :
- edsair.doi...........3a5dca9a189ea296d072abc7db14036b
- Full Text :
- https://doi.org/10.35754/0234-5730-2021-66-2-280-311