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National clinical recommendations for the diagnosis and treatment of mastocytosis

Source :
Russian journal of hematology and transfusiology. 66:280-311
Publication Year :
2021
Publisher :
National Medical Research Center of Hematology of the Ministry of Health of the Russian Federation, 2021.

Abstract

Introduction. Recommendations cover the current state of diagnosis and treatment of mastocytosis.Aim — а consolidation of the Russian experts’ opinion on treatment for adult mastocytosis.Main findings. The recommendations have been developed taking into account foreign literature, national experience and world clinical evidence on therapy for systemic and cutaneous mastocytoses, mast cell leukaemia and other mastocytosis forms. The significance of bone marrow and peripheral blood molecular genetic testing for the presence of KITD816V gene variants is demonstrated. The treatment regimens described are based on midostaurin, imatinib, cladribine, hydroxycarbamide, interferon alfa and haematopoietic stem cell transplantation. Prognosis in different forms of mastocytosis is provided.

Details

ISSN :
24113042 and 02345730
Volume :
66
Database :
OpenAIRE
Journal :
Russian journal of hematology and transfusiology
Accession number :
edsair.doi...........3a5dca9a189ea296d072abc7db14036b
Full Text :
https://doi.org/10.35754/0234-5730-2021-66-2-280-311