Back to Search
Start Over
Early detection of CIN3 and cervical cancer during long-term follow-up using HPV/Pap smear co-testing and risk-adapted follow-up in a locally organised screening programme
- Source :
- International Journal of Cancer. 135:1408-1416
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- We evaluated compliance with human papillomavirus (HPV) testing and risk-adapted patient pathways and monitored changes in high-grade cervical disease during long-term follow-up. Women aged >30 years attending routine screening for cervical cancer were managed according to results from first-round screening tests (cytology and high-risk HPV; Hybrid Capture 2). Between February 2006 and January 2011, 19,795 of 19,947 women agreed to participate, of whom 4,067 proceeded to a second screening round 5 years after recruitment. Predefined endpoints were compliance, grade 3 cervical intraepithelial neoplasia or cancer (CIN3+), new HPV infection, HPV persistence and abnormal smears in round 2. A total of 765 of 19,795 women (3.9%) in round 1 and 41 of 4,067 (1.0%) in round 2 were referred for colposcopy. Compliance rates with colposcopy were 93.1 and 92.7%, respectively, while histological assessment was performed in 680 of 712 (95.5%) and 36 of 38 (94.7%), respectively. CIN3+ rates were 172 of 19,795 (0.87%; 95% confidence intervals: 0.7-1.0) in round 1 and 2 of 4,064 (0.05%; 95% confidence intervals: 0.006-0.2) in round 2; the difference was statistically significant (Fisher's exact test, p
- Subjects :
- Gynecology
Colposcopy
Cervical cancer
Cancer Research
medicine.medical_specialty
medicine.diagnostic_test
business.industry
Obstetrics
Incidence (epidemiology)
HPV infection
Cancer
medicine.disease
Cervical intraepithelial neoplasia
female genital diseases and pregnancy complications
Confidence interval
Exact test
Oncology
medicine
business
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi...........3a7839fa84b8972ba030fc8e156297c6
- Full Text :
- https://doi.org/10.1002/ijc.28783