The protective effects of paricalcitol on renal ischemia reperfusion induced lung injury

Background: Acute kidney injury (AKI) common and important clinical challenge, and renal ischemia reperfusion (I/R) injury is the major reason of AKI. Renal I/R can lead to lung injury and increased mortality. Aims: This study was designed to evaluate whether paricalcitol may protect lung injury following renal I/R injury via its antioxidant properties. Methods: Rats (n=7 per group) were divided into four groups; control, paricalcitol, I/R, and paricalcitol+I/R. Rats were received daily intraperitoneal injection of paricalcitol (0.3 μg/kg) for 5 days in paricalcitol and paricalcitol+I/R groups. On day six, rats were subjected to I/R injury (60 minutes of left renal artery occlusion followed by 60 minutes of reperfusion) after right nephrectomy. Renal function tests, oxidant and antioxidant parameters, and lung histology of both groups were examined. Results: Rats treated with paricalcitol prior to ischemia reperfusion injury exhibited significant reduction in terms of serum and lung tissue malondialdehyde and totaloxidant status levels and significant increase in terms of serum and lung tissue nitric oxide and total antioxidant capacity levels levels (p Conclusions: Paricalcitol may ameliorate renal I/R induced lung injury by attenuating oxidative stress. Figure 1 Serum and lung tissue antioxidant parameters NO;nitric oxide TAC;total antioxidant capacity Pari;paricalcitol # p ## p