Direct aroylation of β-cyclodextrin on the secondary hydroxyl face: a convenient equilibrium-dependent preparation of mono-3-aroyl-β-cyclodextrin via C2-O-aroyl to C3-O-aroyl group migration

A new and convenient method is presented for the preparation of mono-3-O-benzoyl-β-cyclodextrin by direct regioselective benzoylation of β-cyclodextrin using N-benzoylimidazole in carbonate buffer solution. This process involved equilibrium-dependent C2-O-aroyl to C3-O-aroyl group migration to improve the yield.