ChemInform Abstract: Highly Regioselective C-H Bond Functionalization: Palladium-Catalyzed Arylation of Substituted Imidazo[1,2-a]pyridine with Aryl Chlorides

We have developed an efficient Pd-catalyzed regioselective arylation of substituted imidazo[1,2-a]pyridines with aryl chlorides, which is rarely reported. This methodology has been successfully applied to the synthesis of a variety of substituted imidazo[1,2-a]pyridine core π systems which exhibit a wide range of biological activities in many drugs.