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AMPA receptor localization in trigeminal ganglion and its upregulation in migraine

Authors :
Kumaresan M
G. Karthikeyan
Maria Francis Yuvaraj
Gunapriya R
A. Priyadharshini
Senthil Murugan
Siva T
P. K. Sankaran
Source :
International Journal of Research in Pharmaceutical Sciences. 10:2209-2212
Publication Year :
2019
Publisher :
GP Innovations Pvt. Ltd., 2019.

Abstract

Migraine is characterized by headache due to imbalance between excitation and inhibition of neurons disabling normal day to day activities. The excitations of neurons are done by excitatory neurotransmitter glutamate which plays the key role in creating any pathology related to neurons. This study was done to identify GluR1 a subunit of AMPA glutamate receptor in the cells of trigeminal ganglion after inducing migraine and compare it with control rats. The GluR1 subunits were localized in the cytoplasm of neurons, and these subunits were up-regulated following a migraine. The GluR1 was also localized in satellite glial cells and nerve fibers, indicating these subunits expressed in neurons and migrate during nociceptive sensitization. This GluR1 expression in the cells of trigeminal ganglion may be crucial in nociceptive sensitization leading to migraine and other painful conditions like trigeminal neuralgia.

Details

ISSN :
09757538
Volume :
10
Database :
OpenAIRE
Journal :
International Journal of Research in Pharmaceutical Sciences
Accession number :
edsair.doi...........3bb40690ea38db931d7ea39f40b5bda7
Full Text :
https://doi.org/10.26452/ijrps.v10i3.1453