72-OR

Objectives In 2013 the American Task force on Hypertensive diseases defined new criteria for preeclampsia (pet) without proteinuria and excluded the severity of proteinuria from criteria defining pet with severe signs. Still, the majority of women presenting with pet also exhibit proteinuria. It remains disputed whether isolated proteinuria is part of the pet continuum or whether it is a physiological alternation in kidney function in pregnancy. Our aim was to examine maternal and neonatal outcomes of isolated proteinuria and define risk factors for progression to pet. Methods Retrospective cohort study. Data from all hospitalized pregnant women with isolated proteinuria of over 300 mg/24 h at admission between 2009 and 2014, was obtained. We followed this study group from the time of admission to the hospital to the time of discharge postpartum, obtaining maternal and neonatal outcomes. Results During the 5 year period 99 women were diagnosed with isolated proteinuria. 13 women developed pet during pregnancy, and an additional 8 developed pet postpartum (21%). No risk factors for proteinuria were found, however the earlier the diagnosis of proteinuria the higher were the maximal values of proteinuria reached. Risk factors for progression of pet were primiparity (p = 0.01) and greater values of proteinuria (p = 0.005). Among women who developed pet, an earlier diagnosis was made for those with early onset proteinuria (p = 0.002), well established risk factors for pet (p = 0.01) and multiple gestations (p = 0.002). Neonatal outcome was equivocal regardless of progression to pet and levels of proteinuria. Conclusions To date this is the largest series of women with isolated proteinuria followed to term. We conclude that isolated proteinuria is a risk factor for pet, with greater chances of developing pet among primiparous women with higher values of proteinuria. While proteinuria itself is negligible, chances of pet are high and close follow-up is recommended until after delivery. Disclosures S. Shinar: None. A. Schwartz: None. M. Ram-Weiner: None. M. Kupferminc: None. A. Many: None.