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Mechanisms of acquired afatinib resistance in HER2-positive breast cancer cells

Authors :
Bryan T. Hennessy
Alexandra Canonici
Neil T Conlon
Alex J Eustace
Mattia Cremona
Clare Morgan
Norma O'Donovan
John Crown
Source :
Journal of Clinical Oncology. 33:620-620
Publication Year :
2015
Publisher :
American Society of Clinical Oncology (ASCO), 2015.

Abstract

620 Background: Afatinib is a potent irreversible ErbB family tyrosine kinase inhibitor. We have previously shown that afatinib has anti-proliferative activity in a panel of 8 HER2 positive breast ...

Details

ISSN :
15277755 and 0732183X
Volume :
33
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi...........3d905a319f983abeb998a0b8d78260d0
Full Text :
https://doi.org/10.1200/jco.2015.33.15_suppl.620