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Sphenostylis stenocarpa Seed Extract Attenuates Dyslipidemia in Testosterone Propionate-induced Benign Prostatic Hyperplasia in Rats
- Source :
- Pakistan Journal of Biological Sciences. 24:151-157
- Publication Year :
- 2021
- Publisher :
- Science Alert, 2021.
-
Abstract
- BACKGROUND AND OBJECTIVE Benign Prostatic Hyperplasia (BPH) is a prevalent disease among older men caused by abnormal proliferation of the prostatic cells. Findings indicate an association between dyslipidemia and BPH. This study aimed at evaluating the effect of ethanol extract of Sphenostylis stenocarpa seed on the lipid profile of rats with testosterone propionate-induced BPH. MATERIALS AND METHODS A total of 25 male Wistar rats randomized into five groups of five rats each were used. BPH was induced in the rats by subcutaneous injection of testosterone propionate in olive oil for 28 days. The test rats (after BPH induction) were treated with ethanol extract of the plant seed at doses of 200 and 400 mg kg-1 b.wt. The concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triacylglycerol were evaluated on the sera of the rats. RESULTS The BPH control rats (model group) showed a significant (p
- Subjects :
- Testosterone propionate
medicine.medical_specialty
Ethanol
medicine.diagnostic_test
business.industry
Hyperplasia
urologic and male genital diseases
medicine.disease
Subcutaneous injection
chemistry.chemical_compound
Endocrinology
chemistry
Oral administration
Internal medicine
Medicine
lipids (amino acids, peptides, and proteins)
business
Lipid profile
Agronomy and Crop Science
Testosterone
Dyslipidemia
Subjects
Details
- ISSN :
- 10288880
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Pakistan Journal of Biological Sciences
- Accession number :
- edsair.doi...........3de8c755a1c5df90985e81d806e7de24