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Highly Efficient Synthesis of Polysubstituted 2-Aminopyrroles via a Multicomponent Domino Reaction
- Source :
- Synlett. 29:922-927
- Publication Year :
- 2018
- Publisher :
- Georg Thieme Verlag KG, 2018.
-
Abstract
- A highly efficient approach to polysubstituted 2-amino­pyrroles containing a coumarin derivative unit at the 5-position of the pyrrole ring was developed via a novel multicomponent domino reaction of glyoxal monohydrate derivatives, anilines, coumarin derivatives, and malononitrile. This transformation proceeded via an α-amino­ketone as the key intermediate.
Details
- ISSN :
- 14372096 and 09365214
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Synlett
- Accession number :
- edsair.doi...........3e2bf7b90aaa2e37c652eeb499e0ccf9
- Full Text :
- https://doi.org/10.1055/s-0036-1591907