A brief history of poststroke depression neuroimaging

The past 25 years have witnessed a dramatic rise and fall in clinical research investigating lesion localization in poststroke depression patients. Early studies focused on basic lesion characteristics, such as left versus right hemisphere and anterior versus posterior location, that would dominate studies in this field for the next 15 years. While results were inconsistent, some studies suggested that the left hemisphere and more anterior lesions were associated with increased prevalence and severity of depression. Recent studies have suggested lesion preference in components of the basal ganglia and frontal–subcortical circuitry and have proposed a combined effect of large stroke lesions and other lesions, such as white matter hyperintensities and lacunar infarcts. The effect of lesion location on poststroke depression requires further clarification.