Ruthenium bipyridine sensitized MoO3 multifunctional nanostructures: Study of opto-electrochemical properties, biocompatibility and bioimaging

Simple and versatile methodology to synthesize hybrid nanostructures with multi-functionality for device application is advantageous. Herein, we report the synthesis of MoO 3 nanostructures integrated with [Ru(bpy) 3 ] 2+ and PEGylation to obtain hybrid MoO 3 -[Ru(bpy) 3 ] 2+ nanostructures. Chemically interacted [Ru(bpy) 3 ] 2+ provides optical and electrochemical properties to the hybrid structures. PEG 3k enhances the aqueous solubility of the hybrid system. Morphology, chemical structure, optical and electrochemical properties of hybrid nanostructures were studied from electron microscopic, spectroscopic and voltammetric techniques. The synthesized hybrid nanostructures exhibited a metal-to-ligand charge transfer absorbance and emission bands in the range of 450 nm and 605 nm, respectively. Electrode modified with MoO 3 -[Ru(bpy) 3 ] 2+ and MoO 3 -[Ru(bpy) 3 ] 2+ /PEG 3k exhibit improved voltammetric properties than pristine MoO 3 . Confocal cellular imaging supported that these hybrid particles were easily uptaken by endothelial cells with minimal cytotoxic effects. The hybrid nanocomplex displayed unique opto-electrochemical, cellular biocompatibility and imaging features that may be an ideal platform for electrochemical biosensor devices with simultaneous bioimaging function.