Screening of Fungi Producing Alkaline Protease from n-Paraffins and Induction of Kabicidin Resistant Mutant of Fusarium sp

To establish a novel process for the economical production of alkaline protease from n-paraffins by fungi, the variety of fungi were screened for the production of alkaline protease from n-paraffins and Fusarium sp. S–19–5 was selected as an excellent strain, and then the attempt was made to obtain some mutants capable of producing alkaline protease in high yield. A kabicidin resistant mutant No5-128B, was successfully obtained from Fusarium sp. S–19–5 by treatment with ultraviolet light. This mutant No5–128B showed high productivity of alkaline protease, about ten times that of the parent strain. The morphological characteristics and growth response to Kabicidin of the mutant No5–128B were compared with those of the parent stain.