In VitroMammalian Cytogenetic Tests

In vitro cytogenic tests are undertaken in any cancer risk assessment process for exposures to environmental chemicals. Hazard identification is the first step in the cancer risk assessment process. A hazard is considered to be represented by genetic alterations assessed as gene mutations or chromosomal alterations. This article focuses on the numerical and structural induction of chromosomal alterations. Keywords: In vitro cytogenic tests; chromosomal alteration; cancer risk assessment; cancer–research; gene mutations