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Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca²+/Calmoduline-Dependent Protein Kinase II
- Source :
- Synthesis. 2010:4193-4198
- Publication Year :
- 2010
- Publisher :
- Georg Thieme Verlag KG, 2010.
-
Abstract
- Convenient synthetic routes to KN-93, N-(2-{[[(2 E)-3-(4-chlorophenyl)prop-2-enyl](methyl)amino]methyl}phenyl)- N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide,a well-known Ca 2 +/calmoduline-dependentprotein kinase II (CaMKII) inhibitor, are described. The methodsproposed start from easily available reagents- and allowready preparation of the final compound in moderate- overallyields. Most of the synthetic steps proposed were microwave assisted.
Details
- ISSN :
- 1437210X and 00397881
- Volume :
- 2010
- Database :
- OpenAIRE
- Journal :
- Synthesis
- Accession number :
- edsair.doi...........41e083d825c46725f90dee31a8ad5a4f