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Chest pain in the absence of obstructive coronary artery disease
Chest pain in the absence of obstructive coronary artery disease
- Source :
- International Journal of Cardiology. 280:19-28
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Patients presenting with chest pain suggestive of coronary artery disease (CAD) who at coronary arteriography appear to be free of obstructive disease have presented a diagnostic and therapeutic challenge since the 1970's. Studies in female patient populations have suggested that this is predominantly a women's syndrome usually caused by microvascular endothelial dependent and independent dysfunction. A critical review of the literature focusing on studies including both women and men revealed that apart from a higher incidence of this syndrome in women there are no clinical relevant differences between both sexes. In women a lower coronary flow reserve has been reported but this appears to be mainly due to a higher basal flow. Important questions with regard to the clinical implications of microvascular dysfunction have yet to be resolved in studies involving women as well as men in which a distinction is made between patients with normal coronary arteries and those with nonobstructive disease.
- Subjects :
- medicine.medical_specialty
business.industry
Incidence (epidemiology)
Coronary flow reserve
Disease
Fractional flow reserve
Chest pain
medicine.disease
Coronary artery disease
Basal (phylogenetics)
Rate pressure product
Internal medicine
medicine
Cardiology
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 280
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi...........428f738696080ecfd4f8e2421cb0532a
- Full Text :
- https://doi.org/10.1016/j.ijcard.2018.09.103