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27 REEVALUATION OF 19 CHILDREN ONCE FOUND TO BE DEFICIENT IN SERUM IgA

27 REEVALUATION OF 19 CHILDREN ONCE FOUND TO BE DEFICIENT IN SERUM IgA

Authors :
W H Hitzig
P Joller
A K Bühler
Source :
Pediatric Research. 13:952-952
Publication Year :
1979
Publisher :
Springer Science and Business Media LLC, 1979.

Abstract

The maturation of the serum IgA system is slow in comparison to IgG and IgM. Adult serum IgA levels in normal children are reached only at the age of ten years. The normal range is broad and individual fluctuations marked. To investigate the maturation of the system and the implications of low serum IgA in infections of the respiratory and gastrointestinal tract as well as the ORL system we reexamined 19 children once found in our laboratory to be deficient in serum IgA. We tested serum IgA, IgA and secretory component in tears of these 19 children. 53% of them showed normalization of these parameters, 26 % had low serum IgA while 4 children remained deficient. Maturation and compensatory mechanisms are discussed.

Details

ISSN :
15300447 and 00313998
Volume :
13
Database :
OpenAIRE
Journal :
Pediatric Research
Accession number :
edsair.doi...........432c11fff9c078b4d2cc6cc30f291c61
Full Text :
https://doi.org/10.1203/00006450-197908000-00043