79 SERUM CYTOKINES AND THE EXPRESSION OF MIRNAS IN THE VISCERAL ADIPOSE OF PATIENTS WITH NON ALCOHOLIC FATTY LIVER DISEASE

Methods: We took advantage of a previous cohort of patients explored by the Fibroscan for the validation of liver stiffness as a marker of fibrosis. Among them, a sub-group of patients was selected according to the following criteria: 1. LB and Fibroscan performed within 7 days, 2. valid Fibroscan (10 measurements), 3. LB samples ≥20mm except for patients with cirrhosis, 4. LB evaluated by two experienced pathologists (a first regular lecture for diagnosis purpose and a second lecture to quantify steatosis). 228 patients were eventually selected (64% men, mean age =48±12 years). The cause of the liver disease was HCV in 153, HBV in 21, alcohol in 30 and non alcoholic fatty liver disease in 24 patients. 35 patients had cirrhosis. Steatosis was quoted as: S0 steatosis ≤10% of hepatocytes (57% of patients), S1: 11–33% (7% of patients), S2: 34–66% (31% of patients), S3: ≥67% (6% of patients). Performance was evaluated in terms of Area Under the Receiver Operating Characteristic (AUROC). Results: Performance in terms of AUROC is summarized in the Table.