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Preparation and In Vitro Release Behaviors of Paclitaxel-Loaded Pluronic F87/Poly(Lactic Acid) Nanoparticle
- Source :
- Advanced Materials Research. :102-107
- Publication Year :
- 2014
- Publisher :
- Trans Tech Publications, Ltd., 2014.
-
Abstract
- Pluronic F87/Poly (lactic acid) block copolymer (PLA-F87-PLA) was synthesized by bulk polymerization. Paclitaxel-loaded PLA-F87-PLA nanoparcticles were prepared by a dialysis method. The loading efficiency was determined by UV. The results showed that the loading efficiency of paclitaxel for PLA-F87-PLA nanoparticles was 69%. In vitro release behavior of paclitaxel-loaded PLA-F87-PLA nanoparticles was studied by HPLC. In vitro release behavior showed an initial rapid release followed by a slow release. The biocompatibility of nanoparticles was measured by MTT. The viability of paclitaxel-loaded PLA-F87-PLA nanoparticles was less than that of free paclitaxel. The results indicated that PLA-F87-PLA copolymer has good biocompatibility.
- Subjects :
- Materials science
Biocompatibility
Bulk polymerization
General Engineering
Nanoparticle
macromolecular substances
respiratory system
Poloxamer
equipment and supplies
High-performance liquid chromatography
Lactic acid
chemistry.chemical_compound
stomatognathic system
chemistry
Paclitaxel
Polymer chemistry
Copolymer
lipids (amino acids, peptides, and proteins)
Nuclear chemistry
Subjects
Details
- ISSN :
- 16628985
- Database :
- OpenAIRE
- Journal :
- Advanced Materials Research
- Accession number :
- edsair.doi...........4402963726cdfe611c92b12bebc3bfa1