Homocysteine levels in implant failure patients: an observational study

Background: Dental implants have been a part of our lives since 1965 when studies of Branemark commenced. Today, ever increasing number of dental implants in total or partial edentulous patients provides an outstanding treatment alternative to conventional prosthetic rehabilitation all around the world. However, widespread use of dental implants has brought alone a gradually increasing condition called “disease of peri-implant tissues”. The present study was conducted for assessing the Homocysteine levels in implant failure patients. Materials & methods: A total of 25 subjects with clinical and radiographic evidence of peri-implantitis and 25 healthy controls were enrolled. Complete demographic and clinical details of all the subjects were obtained. Fasting (minimum of 12hrs) venous blood samples were collected. The venous blood was collected in plain vials which will sent to the laboratory for biochemical analysis and evaluation of systemic parameters of both peri-implantitis group and control group. Serum homocysteine was assessed by means of Elisa Immunoassay. Results: Mean serum homocysteine levels among subjects of the control group and peri-implantitis group was 13.27 µmol/L and 25.2 µmol/L respectively. Significant results were obtained while comparing the mean serum homocysteine levels among subjects of the peri-implantitis group and control group.