Back to Search Start Over

Tenofovir-based rescue therapy for chronic hepatitis B patients who had failed treatment with lamivudine, adefovir, and entecavir

Tenofovir-based rescue therapy for chronic hepatitis B patients who had failed treatment with lamivudine, adefovir, and entecavir

Authors :
Seok Won Jung
Shi Jung Sung
Sung-Jo Bang
Byung Uk Lee
Min-Ho Kim
In Du Jeong
Chang Jae Kim
Neung Hwa Park
Bo Ryung Park
Eun Hye Kim
Jung Woo Shin
Jae Ho Park
Jae Hee Kim
J. H. Park
Byung Gyu Kim
Source :
Journal of Gastroenterology and Hepatology. 30:1514-1521
Publication Year :
2015
Publisher :
Wiley, 2015.

Abstract

Background and Aim In the past decade, many chronic hepatitis B (CHB) patients have undergone sequential treatment with lamivudine (LAM), adefovir (ADV), and entecavir (ETV) to manage antiviral resistance or insufficient suppression of HBV-DNA. Very limited data are available on the efficacy of tenofovir (TDF) rescue regimens in patients with multidrug resistance (MDR). Methods We investigated the antiviral efficacy of TDF/LAM combination therapy versus TDF/ETV combination therapy in 52 patients who failed three previous antiviral therapies. Results The study subjects were treated with TDF/LAM combination therapy (n = 25) or TDF/ETV combination therapy (n = 27) for more than six months. Virologic response (VR) occurred in 39 (75%) patients (19 patients belonged to the TDF/LAM group and 20 patients belonged to the TDF/ETV group). The VR rates were not different between the TDF/LAM and TDF/ETV groups (56.0% vs 51.9% at month 12, and 72.0% vs 78.8% at month 18; log rank P = 0.515). In addition, treatment efficacy of TDF/LAM combination or TDF/ETV combination was not statistically different according to types of MDR. In multivariate analysis, absolute HBV-DNA level at the start of TDF rescue treatment (P

Details

ISSN :
08159319
Volume :
30
Database :
OpenAIRE
Journal :
Journal of Gastroenterology and Hepatology
Accession number :
edsair.doi...........44b1466134d008bdf98ef1ddef761429
Full Text :
https://doi.org/10.1111/jgh.12993