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ChemInform Abstract: New γ-Fluoromethotrexates Modified in the Pteridine Ring: Synthesis and in vitro Immunosuppressive Activity
- Source :
- ChemInform. 31
- Publication Year :
- 2000
- Publisher :
- Wiley, 2000.
-
Abstract
- Our continuing program to develop new antifolate drugs useful against rheumatoid arthritis led us to modify the pteridine ring of gamma-fluoromethotrexate. Pyrrolopyrimidine derivatives 1e and 1t were found to exhibit potent suppressive effects on the responses of both T and B cells to mitogens, although tetrahydropyridopyrimidine derivatives 2e and 2t and quinazoline derivatives 3e, 3t and 4e showed very weak suppressive activities. Thus, conversion of the pteridine ring of gamma-fluoromethotrexate to a pyrrolopyrimidine ring led to a new potential antirheumatic compound.
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........44cbbaec267619175632108e80c53158