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Study on Antibiotic Loaded Nanoparticles for Oral Infection Treatment

Authors :
Mihaela Moscu
Eduard Radu Cernei
Georgeta Zegan
Daniela Anistoroaei
Elena Mihaela Carausu
Vasilica Toma
Source :
Revista de Chimie. 70:1712-1714
Publication Year :
2019
Publisher :
Revista de Chimie SRL, 2019.

Abstract

Over the past decade, exploitation of antimicrobial effect of nanoparticles on viruses, fungi and bacteria, respectively have developed markedly. A close attention was received by the possibility of nanoparticles type drug delivery systems to limit the biofilm formation within the oral cavity due to their important properties such as delivery abilities, anti-adhesive and biocidal features. The major objective of this work was to obtain doxycycline-loaded chitosan nanoparticles and to analyze the properties of as prepared samples in order to prolong the antibiotic release. The synthesized nanoparticles had less than 100 nm using the classis or improved drug encapsulation technique in chitosan matrix. The study focused on the antimicrobial characteristic of nanoparticles for controlling oral infections.

Details

ISSN :
26688212 and 00347752
Volume :
70
Database :
OpenAIRE
Journal :
Revista de Chimie
Accession number :
edsair.doi...........455f033d2f6a885ec84508257b42a198
Full Text :
https://doi.org/10.37358/rc.19.5.7199