ChemInform Abstract: CHOLINERGIC COMPOUNDS. VII. SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SOME TRIMETHYLAMMONIUM IODIDES RELATED TO DESETHERMUSCARINE

Authors :: Pigini P
Rossini L
L. Re
Pigini M
Carlo Melchiorre
Gamba G
Cingolani Ml
Gualtieri F
Giannella M
Source :: Chemischer Informationsdienst. 7
Publication Year :: 1976
Publisher :: Wiley, 1976.
Abstract: Some substances similar to desethermuscarine were synthesized and studied as cholinergics on isolated organs. The results show the importance of the cyclopentane nucleus with regard to activity. The activity of 3-methyltrimethylammonium hexane iodide is particularly interesting for, though lacking the oxygenated function in 3 and having a different methyl spatial arrangement, this compound is only ten times less active than desethermuscarone.

Subjects :: chemistry.chemical_classification
Desethermuscarine
Stereochemistry
Iodide
Biological activity
General Medicine
Hexane
chemistry.chemical_compound
medicine.anatomical_structure
chemistry
medicine
Cholinergic
Cyclopentane
Nucleus
Function (biology)

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