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Ortho versus adjacent-benzylic directed lithiations of substituted N,N-diethylbenzamides
- Source :
- Tetrahedron Letters. 37:1335-1338
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Directed lithiation of substituted 2- n -alkyl N,N -diethylbenzamides gave mixtures of ortho and adjacent-benzylic alkylated products ( 2 and 3 ). The ratios of isolated products were dependent upon the substitution patterns of the benzene ring and on the reaction conditions. Substrates and reaction conditions that favor either ortho or adjacent-benzylic lithiation are presented.
Details
- ISSN :
- 00404039
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........45706d3db9197b29b79194a0bf7418f3
- Full Text :
- https://doi.org/10.1016/0040-4039(96)00016-0