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Effects of Preloading of Stannous Compounds on the Distribution of 99mTc-Pertechnetate
- Source :
- Nuklearmedizin. 16:26-29
- Publication Year :
- 1977
- Publisher :
- Georg Thieme Verlag KG, 1977.
-
Abstract
- Summary 99mTc-pertechnetate distribution studies were performed in rabbits and mice following pretreatment between 5—336 hours with various routinely used stannous complexes (HSA, MAA, GHT, DTPA, PYPs) containing different amounts of Sn++ (0.17 —15.0 μ mg/kg). Beyond a concentration of 0.26 mg/kg of Sn++ an alteration in 99mTc-pertechnetate distribution was observed. The red blood cell was found to be the most prominent target. An in-vivo reduction of 99mTc-pertechnetate apparently occurred by the presence of stannous ion within the red blood cell. Preloading time period between 5—24 hours did not alter the uptake of RBC/plasma ratio. Beyond that period it decreased slowly and still persisted up to 2 weeks following pretreatment. RBC/ plasma ratio of 99mTcO4 - increased with increased Sn++ content of various commercially available pharmaceutical kits.
Details
- ISSN :
- 25676407 and 00295566
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Nuklearmedizin
- Accession number :
- edsair.doi...........45bbecc690769f8e16d754d9eb7dd86d