Study of regioselectivity in cyanomethylation of 4-(trifluoromethyl)pyrimidin-2(1Н)-ones

Authors :: Viktor M. Tkachuk
Mykhailo V. Vovk
Serhii V. Melnykov
Volodymyr A. Sukach
Anastasiia V. Vorobei
Source :: Chemistry of Heterocyclic Compounds. 55:66-71
Publication Year :: 2019
Publisher :: Springer Science and Business Media LLC, 2019.
Abstract: Cyanoacetic acid reacted selectively with 4-(trifluoromethyl)pyrimidin-2(1Н)-ones with the formation of Michael addition–decarboxylation products in DMSO solution at 85°С and Mannich reaction products when the reagents were fused together under solventfree conditions.

Subjects :: Trifluoromethyl
010405 organic chemistry
Organic Chemistry
Regioselectivity
010402 general chemistry
01 natural sciences
0104 chemical sciences
chemistry.chemical_compound
chemistry
Cyanoacetic acid
Reagent
Michael reaction
Organic chemistry
Mannich reaction

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