Use of a Combination of Pentoxifylline and Vitamin E in Prevention and Treatment of Radioinduced Soft Tissue Fibrosis: a Literature Survey

Late radiation injuries that occur after a significant period from the moment of completion of the radiation treatment can affect any anatomical structure within the irradiated area and thereby significantly impair the quality of life of cancer patients. Modern technologies of radiation therapy and scientifically based dose fractionation modes of radiation exposure have contributed to a significant reduction in the incidence of late radiation damage, but the risk of their appearance remains. The review presents literature data on both the treatment and the possibilities of drug prevention of late radiation damage, such as radio-induced soft tissue fibrosis.