Making Room in the Parking Lot for More Cars - How Changes to Autologous Collection Targets for Patients with Multiple Myeloma Optimized Resource Utilization in the Apheresis Collection Center and Cell Storage Facility at Dana-Farber Cancer Institute

Introduction With rapidly increasing demand, resources at cellular therapy centers may be stretched thin. Apheresis and processing lab facilities must meet increased collection, processing, and storage requests, necessitating efficiency. We queried the field's practice of collecting autologous stem cells for 2 transplants in adult multiple myeloma (MM) patients under 65 for efficiency and clinical relevance as MM collections consume significant cell therapy resources. Methods Data points from 2012, 2014, and 2016 for MM patients at DFCI were reviewed: percentage of patients who received first and second transplants after autologous collection, days of collection, and excess hematopoietic progenitor cell HPC(A) bags in cryostorage. MM clinician leadership discussed existing guidelines and clinical rationale for HPC(A) collection targets. After changes implemented in Feb. 2018, collection and storage data was compiled to assess impact. Apheresis & Cell Storage Data Prior to Change From Jul. to Dec. 2017, MM patients Clinical Practice Patterns & Change in Guidelines Before Feb. 2018, autologous MM collection target for patients Apheresis & Cell Storage Results Following Change Between Feb. – Jul. 2018, the total collection days for adult autologous MM patients Conclusion Reducing autologous collection targets for MM patients