cis-Clerodane diterpenoids from the Chinese liverwort Scapania parva Steph

Three undescribed cis -clerodane lactones, scapanialides A–C ( 1–3 ), and a new cis -clerodane furano-diterpenoid, scaparvin F ( 4 ), were isolated from the Chinese liverwort Scapania parva Steph. Scapanialide B ( 2 ) is the first cis -clerodane diterpenoid with a bicyclo[5.4.0]undecane skeleton from liverworts. Their structures including the absolute configurations were determined by extensive analysis of multidimensional NMR spectroscopy and TDDFT CD calculations, together with crystal X-ray diffraction measurements. The cytotoxicity of compounds 1–4 was preliminary tested against the Hela and MCF-7 cell lines.