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cis-Clerodane diterpenoids from the Chinese liverwort Scapania parva Steph
- Source :
- Phytochemistry Letters. 5:535-540
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Three undescribed cis -clerodane lactones, scapanialides A–C ( 1–3 ), and a new cis -clerodane furano-diterpenoid, scaparvin F ( 4 ), were isolated from the Chinese liverwort Scapania parva Steph. Scapanialide B ( 2 ) is the first cis -clerodane diterpenoid with a bicyclo[5.4.0]undecane skeleton from liverworts. Their structures including the absolute configurations were determined by extensive analysis of multidimensional NMR spectroscopy and TDDFT CD calculations, together with crystal X-ray diffraction measurements. The cytotoxicity of compounds 1–4 was preliminary tested against the Hela and MCF-7 cell lines.
Details
- ISSN :
- 18743900
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Phytochemistry Letters
- Accession number :
- edsair.doi...........4882dadfb45a0e9be4f59cef0b6bb05d