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A pyrazole-containing hydrazone for fluorescent imaging of Al3+ in lysosomes and its resultant Al3+ complex as a sensor for F−
- Source :
- Talanta. 203:178-185
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- A fluorescence-enhanced and lysosome-targeted Al3+ probe (1) based on a pyrazole-containing hydrazone was developed in this work. The fluorescent probe 1 displays an OFF–ON fluorescence response to Al3+ in the lysosome pH environment. In addition, the resultant 1–Al3+ complex could act as an ON–OFF fluorescence sensor for F−. Fluorescence imaging shows that 1 is suitable for visualization of Al3+ in lysosomes of HeLa cells.
- Subjects :
- chemistry.chemical_classification
Fluorescence-lifetime imaging microscopy
integumentary system
biology
Chemistry
010401 analytical chemistry
Hydrazone
02 engineering and technology
Pyrazole
021001 nanoscience & nanotechnology
biology.organism_classification
Fluorescent imaging
01 natural sciences
Fluorescence
0104 chemical sciences
Analytical Chemistry
HeLa
chemistry.chemical_compound
medicine.anatomical_structure
Lysosome
medicine
Biophysics
0210 nano-technology
Fluorescence response
Subjects
Details
- ISSN :
- 00399140
- Volume :
- 203
- Database :
- OpenAIRE
- Journal :
- Talanta
- Accession number :
- edsair.doi...........49178bab3645053271d21fee5cf0ce23