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Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
- Publisher :
- Springer Science and Business Media LLC
-
Abstract
- In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
- Subjects :
- Intracellular Signaling Peptides and Proteins
Proteins
Polymorphism, Single Nucleotide
3. Good health
Pancreatic Neoplasms
Repressor Proteins
Hepatocyte Nuclear Factor 4
Tensins
Databases, Genetic
Humans
Intercellular Signaling Peptides and Proteins
Genetic Predisposition to Disease
Carcinoma, Pancreatic Ductal
Genome-Wide Association Study
Hepatocyte Nuclear Factor 1-beta
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........494a3b731359f4872c2091993e70bcd5