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Nonseminomatous germ-cell cancer of the testis. Reducing treatment-related morbidity in patients with disseminated disease

Authors :
Hyman B. Muss
Richards F nd
Charles L. Spurr
B. R. Paschal
Douglas R. White
Cooper Mr
John J. Stuart
Don V. Jackson
Source :
Cancer. 50:668-671
Publication Year :
1982
Publisher :
Wiley, 1982.

Abstract

Fourteen previously untreated patients with metastatic nonseminomatous germ-cell cancer of the testis (NSGC) were treated with a modified VAB-4 regimens that was designed to reduce treatment-related morbidity. Nine of ten patients with minimal disease and the only patient with advanced pulmonary disease achieved a complete response (CR) with chemotherapy alone. Two of three partial responders with advanced abdominal disease were converted to CR status with radiotherapy and/or surgery. None of the 12 CRs has had a relapse (median duration of follow-up, 28+ months). We observed no granulocytopenic fever or permanent renal insufficiency. These results indicate that NSGC patients with a low tumor burden can be spared substantial toxicity without the complete response rates being adversely affected.

Details

ISSN :
10970142 and 0008543X
Volume :
50
Database :
OpenAIRE
Journal :
Cancer
Accession number :
edsair.doi...........4a318bf4b3e43907d1c430fb60385bcb
Full Text :
https://doi.org/10.1002/1097-0142(19820815)50:4<668::aid-cncr2820500408>3.0.co;2-k