Manufacture of microfluidic chips using a gap-control method based on traditional 3D printing technique

The solution to the commercialization of polymer microfluidic chips lies in the development of a low-cost and concise method. We present in this paper a gap-control method for obtaining low cost microfluidic chips on PMMA (polymethyl methacrylate) sheets based on traditional 3D printing technique—fused deposition modeling. The influence of 3D printing parameters such as printing temperature, printing speed, wire flow rate and initial layer thickness on printing quality is studied by experiments. The effect of O2 plasma parameters such as chamber power and treatment time on the adhesion strength between printed PLA (polylactic acid) structures and PMMA substrate is investigated. The dye filling tests demonstrate that there is no blocking or leakage over the entire microchannels. With this newly developed technology, low-cost and large scale microfluidic chips can be fabricated, which allows commercial manufacturing of microchannels over large areas.