Lymphoepithelial carcinoma in the submandibular salivary gland: A rare case report

Lymphoepithelial carcinoma (LEC) is a rare tumor characterized by the undifferentiated or poorly differentiated malignant epithelial cells with marked reactive lymphoplasmacytic infiltrate. In the major salivary glands, LEC commonly occurs in the parotid gland and rarely seen in the submandibular gland. We present a case of submandibular gland LEC found in a 64 years-old Japanese male with Epstein-Barr virus infection. The patient underwent radical neck dissection and postoperative chemoradiotherapy. No evidence of recurrence has been detected during the 5-year follow-up.