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Outsourcing CREB translation to axons to survive

Authors :
Christine E. Holt
Andrew C. Lin
Source :
Nature Cell Biology. 10:115-118
Publication Year :
2008
Publisher :
Springer Science and Business Media LLC, 2008.

Abstract

Nerve growth factor induces sensory neuron survival via retrograde signalling from the axon to the cell body. Local translation of the transcription factor CREB in the axon, followed by its transport to the nucleus, is involved in this process.

Details

ISSN :
14764679 and 14657392
Volume :
10
Database :
OpenAIRE
Journal :
Nature Cell Biology
Accession number :
edsair.doi...........4b26600855e7ab7626e8f283ca6e296b
Full Text :
https://doi.org/10.1038/ncb0208-115