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Synthesis and neuropharmacological activity of N-1-adamantylcytisine-12-carbamide and its 12-thiocarbonyl analog
- Source :
- Chemistry of Natural Compounds. 49:707-711
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- The neuropharmacological activity of two (–)-cytisine derivatives with adamantyl fragments was studied. It was shown that N-1-adamantylcytisine-12-thiocarbamide exhibited in tests in vivo a pronounced mnestic effect, increased the lifespan of laboratory animals under hypoxic conditions, and also enhanced in vitro binding of transcription factors NFAT and NF-κB to the DNA sequences corresponding to them.
Details
- ISSN :
- 15738388 and 00093130
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Chemistry of Natural Compounds
- Accession number :
- edsair.doi...........4b8188f0c084450a708824c061da6687