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Features of the immune response and vascular wall stiffness in workers exposed to industrial aerosols

Authors :
M. Y. Milyutina
E. V. Makarova
Ju. V. Ivanova
Source :
Russian Journal of Occupational Health and Industrial Ecology. 1:850-854
Publication Year :
2019
Publisher :
FSBI Research Institute of Occupational Health RAMS, 2019.

Abstract

Introduction. In recent years, in occupational pathology, much attention is paid to professionally caused diseases, a special place among which is occupied by cardiovascular pathology. Vascular wall stiff ness is considered as an independent cardiovascular risk factor. This makes it important to study the mechanism of development of arterial stiffness, a key component of which is inflammation.The aim of the study was to identify the relationship between immune parameters and vascular wall stiff ness according to volumetric sphygmography in workers exposed to industrial aerosols.Materials and methods. A survey was conducted of 55 men working in conditions of exposure to industrial aerosols, and 32 men who do not have professional contact with industrial pollutants. Serum concentrations of class A and G immunoglobulins, cytokines, tumor necrosis factor α, and C-reactive protein were determined by solid-phase enzyme immunoassay. Assessment of elastic properties of the vascular wall was carried out by volumetric sphygmography.Results. Increased production of anti-inflammatory interleukin–8, immunoglobulin G and C-reactive protein, as well as increased cardiovascular and ankle vascular index on the right and left in the group working under the influence of industrial aerosols was found. Median concentrations of immunoglobulins, interleukins and C-reactive protein were independent of changes in the value of the cardiovascular ankle vascular index. Increased rigidity of the vascular wall was accompanied by an increase in the production of tumor necrosis factor α. Thus, in the group of persons with increased stiff ness, the level of this cytokine was 3 times higher than in the group of persons with normal values of the cardiovascular-ankle vascular index. The relationship between the cardiovascular ankle vascular index and the concentration of tumor necrosis factor α (r=0.61; p=0.009), C-reactive protein (r=0.54; p=0.02) and feedback with the level of anti-infl ammatory interleukin–10 (r=0.36; p=0.04) was revealed.Conclusions. The established significant correlations between cytokines (tumor necrosis factor α, interleukin–10), C-reactive protein and individual indicators of volumetric sphygmography (cardio-ankle vascular index) indicate the pathogenetic role of cytokines and acute phase proteins in the violation of elastic properties of the vascular bed in workers under the influence of industrial aerosols.

Details

ISSN :
26188945 and 10269428
Volume :
1
Database :
OpenAIRE
Journal :
Russian Journal of Occupational Health and Industrial Ecology
Accession number :
edsair.doi...........4cf4d9ef7ad91f764a48e98b4a3c8e7c