233 KNOCKDOWN OF THE MT1 MELATONIN RECEPTOR AMELIORATES THE PHENOTYPES OF THE MDR2-/- MOUSE MODEL OF PRIMARY SCLEROSING CHOLANGITIS (PSC) BY DOWNREGULATION OF ORPHAN GPR50 RECEPTOR-PROMOTED CONSTITUTIVE TGF-β1 RECEPTOR SIGNALING

Authors :: Romina Mancinelli
Paolo Onori
Gianfranco Alpini
Lindsey Kennedy
Lixian Chen
Heather Francis
Eugenio Gaudio
Domenico Alvaro
Tianhao Zhou
Konstantina Kyritsi
Sanjukta Chakraborty
Shannon Glaser
Guido Carpino
Burcin Ekser
Leonardo Baiocchi
Ludovica Ceci
Kassidy Grumbles
Nan Wu
Chaodong Wu
Antonio Franchitto
Source :: Gastroenterology. 160:S-768
Publication Year :: 2021
Publisher :: Elsevier BV, 2021.

Subjects :: Gene knockdown
Hepatology
Gastroenterology
Biology
medicine.disease
Phenotype
Melatonin receptor
Primary sclerosing cholangitis
Downregulation and upregulation
GPR50
medicine
Cancer research
Receptor
Transforming growth factor

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